The der(1;7) is characterized by a greater male preponderance, marked thrombocytopenia, higher HB, lower ANC, and lower blasts in MDS, with more sole aberration existence and co‐occurrence of +8 in karyotype, and with higher frequencies for RUNX1, ETNK1, and EZH2 mutations. This evidence concerns the gene EZH2 and Thrombocytopenia.