Polygonatum has also been shown to attenuate myocardial fibrosis and inflammation and restore the morphology and function of myocardial tissue by regulating AMPK-Nrf2, NF-κB, TGF-β1/Smads, and NLRP3 inflammasome signaling pathway [152–157]. The gene discussed is NFKB1; the disease is Myocardial fibrosis.