Studies show that the up-regulation of SPHK2 is associated with growth and metastasis in various cancers [21] and that the overexpression of SPHK2 can inhibit the cellular apoptosis of NSCLC, suggesting that the activity of SPHK2 is related to the development and prognosis of lung cancer [22]. The gene discussed is SPHK2; the disease is non-small cell lung carcinoma.