In addition to those tumors, our current study not only observes the up-regulated expression of GPR137 in STAD using online database, but also clarifies the function of GPR137 in regulating GC cell biological actions, including proliferation, migration, invasion, colony formation in vitro as well as xenograft growth in nude mice in vivo, suggesting that GPR137 could also be a potential therapeutic target for GC. Here, GPR137 is linked to gastric cancer.