In addition, the enrichment analysis of the top 20 pathways from KEGG also exhibited that GPR137 was correlated with multiple pathways in cancer (Fig. 3C), including Notch, RTK-RAS, WNT, Hippo, PI3K, Myc, TGF-Beta, NRF2 and cell cycle signaling, among which Hippo signaling revealed the largest pathway size with more affected genes (Fig. 3D). This evidence concerns the gene TGFB1 and cancer.