Additionally, Xia et al. [42] showed that methyltransferase 5, N6-adenosine (METTL5) can also stabilize c-MYC through several pro-oncogenic USP5-c-MYC signaling cascades, thereby enhancing the proliferation and migration of hepatocellular carcinoma (HCC) cells. This evidence concerns the gene USP5 and hepatocellular carcinoma.