While our analysis of ChIP-seq data from the Cistrome Data Browser indicated a pronounced enrichment of c-MYC binding peaks located away from the EFTUD2 promoter region in multiple CRC cells (Fig. S2B), our ChIP-qPCR and dual luciferase reporter assays provided direct evidence of c-MYC’s functional binding to the EFTUD2 promoter. Here, MYC is linked to colorectal carcinoma.