A five-gene risk score (P-AML-5G) was then established by integrating the expression levels (normalized counts) and the coefficients derived from multivariable Cox regression analyses, and the formula was exhibited as below: Risk Value = [0.00024149 × COL23A1 expression] + [0.00029096 × TTC38 expression] + [0.00054436 × RNFT1 expression]- [0.000674 × ZNF775 expression] + [0.0001792 × CRNDE expression]. This evidence concerns the gene RNFT1 and acute myeloid leukemia.