A recent multicenter study conducted in non-Hispanic white patients with MASLD and metabolic syndrome, including HCC cases and cancer-free controls, found an association between the PNPLA3 SNP rs738409 (OR, 1.52; 95% CI, 1.27–1.82) and an increased risk of developing HCC.87 This evidence concerns the gene PNPLA3 and hepatocellular carcinoma.