PMS2 and hepatocellular carcinoma: However, a noteworthy finding was that only 7 of the 334 patients (2.1%) harbored a P/LP variant in established cancer-associated genes, specifically PMS2, NBN, FH, or RET. There was a statistically significant higher frequency in P/LP variants in NBN and RAD50, which are involved in the MRE11-RAD50-NBS1 (MRN) complex, when comparing HCC cases with controls.