Most importantly, ATI linked to obesity arising from the chronic accumulation of lipid (trans and saturated fats, low-density lipoprotein - LDL) deposits in AT cells develop from adipocyte extension, deformation, loss of function, and excessive release of pro-inflammatory (IL-1β and TNF-α) compared to anti-inflammatory factors [36]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.