RSPO4 and hypertensive disorder: In conclusion, our main findings included variants in KCNK3, SCN10A (a known cardiac gene), NKAIN2, and the intergenic region between ANGPT4-RSPO4, and aggregate findings in the gene regions of AGTPBP1, MYL4, PDCD4, BBS9, ERG, and IER3. While many of these SNVs and gene regions have prior cardiovascular implications, most have not been associated with HTN or BP phenotypes (except for KCNK3) and remain worthy of further investigation of aTRH.