They focused on a mouse surface and membrane protein-encoding gene library targeting 1,685 genes and demonstrated that adoptive transfer of CD8+ T cells with Pdia3, Mannoside Acetylglucosaminyltransferase 5 (Mgat5), Epithelial Membrane Protein 1 (Emp1) or Lymphocyte-activation gene 3 (Lag3) gene editing enhanced the survival of GBM-bearing mice in both syngeneic and T cell receptor transgenic models (Ye et al., 2019). This evidence concerns the gene LAG3 and glioblastoma.