By harvesting tumors with tumor-infiltrating lymphocytes and analyzing the sgRNA frequency, they re-identified canonical immunotherapy targets such as PD-1 and T cell immunoglobulin and mucin-domain containing-3 (Tim-3), along with genes that have not been characterized in T cells like DEAH-Box Helicase 37 (Dhx37). Here, DHX37 is linked to neoplasm.