Consistent with this, IL-1 signaling triggered increased expression of leukocyte adhesion molecules on endothelial cells, with reduced neutrophils recruited on the endothelium following administration of the IL-1 α receptor inhibitor IL-1 Ra (120), while blockade of IL-1 β signaling reduced the formation of NETs in breast cancer (142). The gene discussed is IL1B; the disease is breast carcinoma.