In this study, WP attenuated the degree of hepatic inflammatory and fat vacuolization alterations in HFD-fed mice, inhibited the increase of adipose tissue and the enlargement of adipocytes in mice epididymis, and at the same time, it could be observed that the levels of LPS, IL-6, IL-1β, TNF-α, and MCP-1 expression in serum of obesity model mice were significantly decreased, and the expression of IL-10 was increased, while the level of the immune factor sIgA increased. Here, IL1B is linked to obesity due to melanocortin 4 receptor deficiency.