positively correlated with BMI and inflammation was significantly reduced (23), and the genera of Lactobacillus and Butyricimonas, which have been demonstrated to be used for the prevention of obesity and the regulation of intestinal microecological balance, and which are capable of preventing HFD-fed mice diabetes and metabolic disorders via GLP-1 receptors, had a significant were all significantly increased in the overall bacterial genus group (17, 24, 25). The gene discussed is GLP1R; the disease is obesity due to melanocortin 4 receptor deficiency.