Molecular analysis of the skin of IgG- and anti-IL36R-treated K14-IL17Aind mice revealed effective suppression of psoriasis-associated cytokines (Il36a, Il36g, Il36b, Il23a, and Tnf), chemokines (Cxcl1, Cxcl5, and Ccl2) (Figure 4G) and antimicrobial-peptides (such as Defb4) on mRNA level (Supplementary Figure 3B). Here, CXCL5 is linked to psoriasis.