Furthermore, whereas IgG-treated K14-IL17Aind mice also displayed psoriasis-associated systemic inflammation, marked by granulopoiesis, myelopoiesis, and an elevated expression of inflammation markers in the spleen, mice that received a short-term treatment with anti-IL36R antibodies displayed a reduction in these markers of systemic inflammation (Supplementary Figures 4B, C). The gene discussed is IL1RL2; the disease is psoriasis.