NFKBIZ and psoriasis: Whereas K14-IL17Aind mice harboring wildtype Nfkbiz expression show severe systemic inflammation and skin lesions all over the whole body at young age (33, 35), keratinocyte-specific, heterozygous depletion of Nfkbiz in these mice renders the mice healthy until an age of 10–11 weeks, when the mice start to develop psoriasis-like skin lesions at the ears and back (34).