When we analysed SLE activity states (LLDAS and DORIS-21), we observed that patients who did not fulfil the LLDAS definition showed a trend towards higher levels of Ang-2 and significantly (p=0.0354) increased sTie1 levels compared to HC and patients that fulfilled these criteria, while Ang-1 levels were significantly (p=0.0445) reduced (Figure 1C). Here, ANGPT2 is linked to systemic lupus erythematosus.