Type I IFN signal through the IFN α/β receptor 1 and receptor 2 (IFNAR1-IFNAR2) and play different roles in SLE, including the activation and skewing of myeloid cells to antigen presenting cells, which lead to the hyperactivation of T and B cells and the production of antibodies (9). The gene discussed is IFNA1; the disease is systemic lupus erythematosus.