Overall, 8 out of 17 inflammation markers that were up-regulated in TB patients were also significantly (p<0.03 - <0.0001) elevated in mod-sev TB as well as anemic TB patients, generating an inflammation response module consisting of BAFF, LIGHT, sTNF-R1 and 2, IP-10, osteopontin, CHI3L1 and IFNα2 (Figures 5A-F; Table S1). The gene discussed is SPP1; the disease is tuberculosis.