Clearly, an immune response profile defined by up-regulated levels of BAFF, LIGHT, sTNF-R1 and 2, IP-10, osteopontin, CHI3L1 and IFNα2 and IL-8, were effective in separating TB patients with different disease clinical severity and were also rapidly down-regulated after start of anti-TB treatment. The gene discussed is SPP1; the disease is tuberculosis.