IL4 and Granuloma: Single-cell sequencing of Mtb granulomas in zebra fish and non-human primates, suggested that spatial organization of granulomas involving a mix of robust Th1 (IFN-γ, IL-12, IL1-β) but also counteracting Th2 (Il-4 and IL-13) responses, were associated with macrophage epithelialization and bacterial control (57).