Contrary, three (sCD163, pentraxin-3 and IL-8) of the top-ranked 9 markers for clinical disease severity (Figures 3E, F) overlapped with the RF analyses comparing extensive with limited lung disease (Figures 3M, N), suggesting that there may be differences in inflammatory mediators involved in clinical and radiological disease severity. The gene discussed is CXCL8; the disease is lung disorder.