TNF and diabetic kidney disease: Compared with the NC group, the proinflammatory cytokine tumor necrosis factor-alpha (TNF-α) in the kidney tissues in the DKD group was significantly increased (P < 0.05), while the anti-inflammatory cytokine interleukin-10 (IL-10) was significantly decreased (P < 0.05) (Figures 2(d) and 2(e)).