The results of qPCR assay showed that the expressions of NACHT, LRR, and PYD domain-containing protein 3 (NLRP3), caspase-1, and interleukin-1beta (IL-1β) in the kidney tissues of DKD model mice were significantly higher than those of the NC group, while these expressions after oral administration of NKK20 were significantly decreased (P < 0.05) (Figures 2(a)–2(c)). This evidence concerns the gene CASP1 and diabetic kidney disease.