Herein, our data show that CIP alone and CIP + PEG after IR effectively (a) recovered megakaryocytes in bone marrow of sternums, (b) recovered GFAP and further increases in GFAP in CIP-treated brains, (c) inhibited C3 and p53 activation, and (d) inhibited intracranial hemorrhage. The gene discussed is C3; the disease is intracranial hemorrhage.