These hub genes comprised IFI44L, ISG15, MX1, IFI44, OASL, RSAD2, GBP1, OAS1, IFI6, and HERC5, which could be potential biomarkers for common pathogenetic processes between COVID-19 and TB and may accelerate the development of novel therapeutic strategies. The gene discussed is ISG15; the disease is COVID-19.