Associations exist between CHIP and several types of cancer, including bladder tumors (38, 140, 141), breast cancer (38, 140–143), colorectal cancer (38, 140, 142, 144, 145), endometrial cancer (38, 140), esophagogastric cancer (38, 140, 143), head and neck cancer (38, 140, 143), kidney cancer (38, 140, 141), lung cancer (38, 140–143), melanoma (38, 140, 141), ovarian cancer (38, 41, 140, 143), pancreatic cancer (38, 140–143), prostate cancer (38, 140–142, 146), and thyroid cancer (38, 140, 141, 143). The gene discussed is STUB1; the disease is cancer.