ERBB2 and breast cancer: Similarly, it was reported in a recent study including 235,368 early breast cancer patients, that the BC subtype distribution differs according to age, with an increase of Luminal BC and decrease of TNBC, Her-positive/HR-positive and Her2-positive/HR-negative BC, with higher age: 46.9%, 29.7%, 15.9%, and 7.5% respectively for age <30-years; 87%, 6.2%, 4.1% and 2.7% respectively for age 70-79 years; and 93.4%, 2.7%, 2.2% and 1.7% for patients age 80-years or older (35).