Two hundred thirty-four patients had pT1pN0-1mi TN (129), HR-Her2+ (30), or ER+Her2+ (75) BC, homogeneously represented in each age group (p=0.461), with 212 patients having pN0 disease (90.6%), 6 pN0(i+) (2.6%) and 16 pN1mi (6.8%) (Supplementary Table 3). This evidence concerns the gene ESR1 and breast cancer.