Hepatic or Renal disease, Ethanol abuse, Malignancy, Older (age >75 years), Reduced platelet count or function, Rebleeding risk, Hypertension (uncontrolled), Anemia, Genetic factors (CYP2C9 single nucleotide polymorphisms), Excessive fall risk (including neuropsychiatric disease), and Stroke. This evidence concerns the gene CYP2C9 and anemia (phenotype).