Opstad et al. demonstrated that the quartiles of serum TIMP-1 levels after myocardial infarction in 243 patients contributed to cardiac remodeling, including a large infarct size, high NT-proBNP levels, and poor LVEF obtained at 3 months (36) Nordeng et al. reported that TIMP-1 was highly expressed in intracoronary thrombi from 33 patients with ST-segment elevation myocardial infarction, mainly connected to monocytes and macrophages. Here, NPPB is linked to myocardial infarction.