ITGAM and stroke disorder: Conversely, diphtheria toxin-induced depletion of CD11b+ cells in transgenic CD11b-DTR mice resulted in an increase of proinflammatory gene expression in both the ipsilateral and contralateral hemispheres (Frieler et al., 2015); likewise, microglia depletion in an animal model of stroke resulted in an enlarged ischemic lesions (Marino Lee et al., 2021).