Studies have shown that VMH SF-1 neuronal activity is markedly enhanced in response to anxiety-like behavior following predator stress exposure (Kennedy et al., 2020), while blockade of VMH glutamate signaling can effectively ameliorate anxiety (Cheung et al., 2015; Li et al., 2023), suggesting that the VMH is involved in the regulation of stress-coping behavior. Here, SF1 is linked to Anxiety.