While there was no difference in death of non-parenchymal cells in the liver, which include liver resident and infiltrating innate immune cells, between WT and Rip3K51A/K51A mice after FFC feeding, we cannot exclude the possibility that the RIP1 kinase-RIP3 kinase-MLKL-axis in hepatic immune cells plays a crucial role in the development of NAFL/NASH. The gene discussed is RIPK3; the disease is metabolic dysfunction-associated steatohepatitis.