FTO and obesity due to melanocortin 4 receptor deficiency: The FTO rs17817449 polymorphism was independently associated with both T2DM (P = 0.04) and dyslipidemia (P = 0.05) after adjusting for the confounding variables including age, sex, smoking, obesity, dyslipidemia, hyperhomocysteinemia, hyperuricemia, hypertension and CAD.