As shown in Tables 5, 6, no significant associations of PPARD rs2016520 and rs2267668 polymorphisms with obesity, dyslipidemia, hyperhomocysteinemia, hyperuricemia, hypertension, T2DM and CAD were detected in the present study (P > 0.05 for all). The gene discussed is PPARD; the disease is obesity due to melanocortin 4 receptor deficiency.