As the rs9939609 and rs17817449 polymorphic sites are localized within FTO, a gene with the strongest association with obesity discovered so far, a large number studies have reported a significant association between the rs9939609 and rs17817449 polymorphisms and obesity among various populations including East and South Asians (52–58), Latin Americans (23, 59–61), Europeans (62), Africans (63) and Middle Easterners (64). This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.