RA, rheumatoid arthritis; DMARDs, disease-modifying antirheumatic drugs; TNF, tumor necrotic factor; JAK, Janus kinase; MPCs, mesenchymal precursor cells; RAMBA, RA memory B cells and Abatacept; anti-CCP, anti-cyclic citrullinated peptide; HAQ, health assessment questionnaire; VTEs, venous thromboembolic events; DRL-R, diagnostic reference level-rituximab; FU, Florida University; EU, European Union. Here, TNF is linked to rheumatoid arthritis.