CBP: Hb: 13.7 g/dL;  Repeat Hb on 3rd DOL: 11 g/dL; WBC & platelets: normal; CRP: 96 mg/L (Normal: <6 mg/L); blood C/S: no bacterial growth; APTT - 56.5 sec; PT: 19.3 sec; INR: 1.4; D-dimer: 7023 ng/mL; FDP: elevated; fibrinogen: elevated; stool for occult blood: positive; NSG–IVH on day 4 of life; MRI on day 8 - intra parenchymal hemorrhages & hemorrhagic infarcts in various stages (Figure 1), large subdural hematoma along frontoparietal, kinking of optic nerves & flattening of sclera. This evidence concerns the gene CRP and Subdural hemorrhage.