MAPT and Alzheimer disease: Treatment of cells expressing 9A 0N/3R or 9E 0N/3R tau with AD tau core 306–378 seeds also induced tau aggregation, and there was more Triton insoluble tau formed with 9A 0N/3R tau compared to 9E 0N/3R tau, but neither were significantly different from WT 0N/3R tau (Figure 11).