MAPT and Alzheimer disease: In the absence of AD tau core seeds, phospho-mimetic and phospho-null tau displayed little tendency for self-aggregation (Figures 7–11), although some self-aggregation of 0N/4R P301L 12A was noted (P301L vs. P301L/12A, p = 0.02 and P301L/12A vs. P301L/12E, p = 0.0108) (Figure 7).