AD tau aggregates are composed of all 6 tau isoforms, those found in PiD are predominantly composed of isoforms consisting of 3-repeat (3R) tau, while aggregates found in CBD predominately consist of 4-repeat (4R) tau (Goedert et al., 1992; Buée and Delacourte, 1999). The gene discussed is MAPT; the disease is pelvic inflammatory disease.