Structurally, these findings have been further explicated by cryo-EM studies which have elucidated the amino acid sequences of the filament core of both PHFs and SFs found in AD, as well as the tau cores of filaments found in PiD and CBD (Fitzpatrick et al., 2017; Falcon et al., 2018a,b; Zhang et al., 2020). Here, MAPT is linked to Alzheimer disease.