AIFM2 and melanoma: Scholars found that the primary role of FSP1 in protecting A549 and H460 cells from ferroptosis was associated with high levels of FSP1-associated proteins, and it is noteworthy that FSEN1 induced a low level of ferroptosis in A375 melanoma cells in the absence of RSL3 combination therapy; these results suggest that A375 cells depend on FSP1 in a particularly strong manner to inhibit ferroptosis.