All are associated with early disease onset and elevated alpha-fetoprotein, while AOA1, AOA2, and AOA4 are further associated with elevated cholesterol and hypoalbuminemia (Papadimitriou et al., 1996; Moreira et al., 2001; Sano et al., 2004; Quinzii et al., 2005; Kijas et al., 2006; Tada et al., 2010; Bogeski et al., 2011; Bras et al., 2015; Paucar et al., 2019; Kato et al., 2021; Coutinho et al., 2023). This evidence concerns the gene AFP and Hypoalbuminemia.