GPT and acne: Our study investigated the prevalence of liver enzyme changes during isotretinoin use in patients with acne. In pre-treatment, second, and last readings, the prevalence rates of AST elevation were 3 (3.1%), 7 (7.2%), and 8 (8.2%), respectively, and the rates of elevated ALT levels were 2 (2.1%), 5 (5.2%), and 4 (4.1%), respectively.