Dueto the essential role of the interaction between Tir and Nck-SH2 inEPEC infection, we envision that a peptide that blocks the protein-bindingsite of the Nck-SH2 domain will inhibit EPEC-mediated pedestal formation,which will block the entrance of EPEC and guard the cells againstEPEC infection (Figure 1). The gene discussed is NCK1; the disease is infection.