SIRT6 and Sepsis: Hsieh et al., 2011 demonstrated that inducing autophagy with rapamycin in a SIMI mouse model could mitigate cardiac dysfunction. Previous studies have also indicated that Sirtuin6 (SIRT6) can activate autophagy and alleviate myocardial depression in sepsis (Tasselli et al., 2017). Additionally, it has been observed that modulation of JNK signaling pathway-dependent autophagy can alleviate sepsis-induced cardiac systolic dysfunction (Wang et al., 2019a).