This latter issue has taken on increasing significance in light of the accumulating evidence that interactions between α7*‐nAChR and toxic, oligomeric, forms of amyloid‐β1‐42 (oAβ42) contribute to memory changes early in Alzheimer's disease and perhaps to cholinergic influences on cognition more broadly.19 The gene discussed is IGKV2D-24; the disease is Alzheimer disease.