[92] Of note, the Aire‐dependent recirculation of mature, peripheral Treg to the thymus is of functional relevance due to the potential of such cells to compete for intrathymic IL‐2 availability and thereby influence IL‐2 dependent intrathymic Treg development.[93] Moreover, recent observations have further revealed that in addition to regulating the re‐entry of peripheral Treg to the thymus, Aire+ mTEC restimulate such recirculating cells and maintain their suppressive function and capacity to attenuate autoimmune disease.[94]. The gene discussed is IL2; the disease is autoimmune disease.