Fezf2‐deficient mice also demonstrate autoantibodies and inflammatory cell infiltration in organs including brain, kidney, liver, and salivary gland, and interestingly the patterns of autoimmunity in Fezf2‐ and Aire‐deficient mice were reported to be non‐overlapping indicating a cooperative role of these pathways and the heterogenous mTEC‐defined by their expression in the regulation of central tolerance. This evidence concerns the gene AIRE and Autoimmunity.