Then, to assess if LXRα was responsible for the effects of Dock5 in podocytes, podocyte‐specific interference of LXRα in Dock5 cKO mice was conducted by AAV2 ‐Nphs1 (podocyte‐specific promoter)‐shLXRα under the DKD condition. This evidence concerns the gene DOCK5 and diabetic kidney disease.