The results showed that despite no differences being observed after Dock5 knockdown under basal conditions, cKO mice exhibited a higher kidney weight‐to‐body weight ratio (KW/BW) and urine albumin‐to‐creatinine ratio (UACR) than their wild‐type (WT) littermates under DKD conditions, despite unchanged blood glucose levels (Figure 3A–C). Here, DOCK5 is linked to diabetic kidney disease.