While EZH2 is capable of binding the NGN3 transcription factor29 it is also appreciated the methyltransferase influences endocrine cell fate of NGN3 positive pancreatic cells.23 In this study, gene expression analysis of GSK126 or Taz stimulated cells from a juvenile T1D donor demonstrated elevated expression of the master regulator of pancreatic endocrine cells, NGN3, which is transiently expressed and modulates downstream target genes resulting in a transition of cell identity. This evidence concerns the gene NEUROG3 and type 1 diabetes mellitus.