A case report has recently shown that it is now possible to partly restore insulin gene expression from pancreatic ductal cells by converting the refractory nature of chromatin using GSK126, an FDA-approved EZH2 inhibitor.23 Despite showing the β-cell-like conversion of exocrine cells from a T1D donor with absolute β-cell destruction, residual doubts remained on the generalizability of the n = 1 finding. This evidence concerns the gene EZH2 and type 1 diabetes mellitus.