To identify differentially expressed genes and pathways responsive to pharmacological inhibition of EZH2, we performed RNA sequencing to generate transcriptome profiles from exocrine cells derived from a juvenile Type 1 Diabetes (T1D) donor including pancreatic ductal epithelial cells following stimulation of GSK126 or Taz for 48 h. The gene discussed is EZH2; the disease is type 1 diabetes mellitus.