In another transgenic AD model (3×Tg-AD mice), which displays a combination of Aβ plaques and tau tangles similar to human AD, both hippocampal and cerebrospinal fluid delivery of AAV9-TRIM11 reduced tau pathology, decreased hippocampal astrogliosis and microgliosis, and ameliorated cognitive impairment (Fig. 1e). This evidence concerns the gene MAPT and Cognitive impairment.