KEAP1 and cancer: Nrf2 is vigorously located in the nucleus to induce an anti-oxidative reply in intense oxidative pressure because of reactive oxygen species or the build-up of carcinogens.68 Tumorigenicity is regulated by two means of the Nrf2 antioxidant reply, either via Keap1-dependent and Keap1-independent mechanisms or via stimulating the development and cancer-cell survival, which are already inducted since Nrf2 and the anti-oxidative reply aids tumors in dealing with oxidative stress.69 Hence, the Nrf2 and its anti-oxidative response could be a suitable target for combinatorial therapy.