Patients with autoimmune diseases, such as active Graves’ hyperthyroidism, have elevated circulating BAFF levels, correlating with increased thyroid hormone and TRAb.360 Additionally, hyperthyroidism is linked to genetic variations of BAFF.361,362 As a result, BAFF could be a therapeutic target for autoimmune diseases driven by B cells. This evidence concerns the gene TNFSF13B and autoimmune disease.