Another co-delivery system of siRNA and Dex using hybrid polymer micelles consisting of polycaprolactone-polyethyleneimine and polycaprolactone-polyethyleneglycol has also shown potential for inhibiting NF-κB signaling pathway in macrophages and polarizing macrophages from M1 to M2 in the arthritic synovium.313 Furthermore, folate acid-modified MTX-conjugated polymer hybrid micelles complexed with miR-124 via electrostatic interaction that targeted the activated macrophages in RA joints achieved the synergistic anti-RA effect in a rat adjuvant-induced arthritis model.314. The gene discussed is NFKB1; the disease is rheumatoid arthritis.