The diminished enrichment of DNMTs and MeCP2, coupled with the heightened abundance of TETs, at Agtr1a and Slc12a2 promoters creates a permissive epigenetic landscape that actively drives the transcription of Agtr1a and Slc12a2 in the PVN (Fig. 8), contributing to the development of hypertension. The gene discussed is SLC12A2; the disease is hypertensive disorder.