A study confirmed that by comparing RA patients with controls, a direct association between TNFB, BsmI, TaqI, MTHFR (C677T, A1298C), TGFβ1, and ApaI polymorphisms, and RA susceptibility has been demonstrated in this study (Saad et al. 2015). This evidence concerns the gene TGFB1 and rheumatoid arthritis.