A study confirmed that by comparing RA patients with controls, a direct association between TNFB, BsmI, TaqI, MTHFR (C677T, A1298C), TGFβ1, and ApaI polymorphisms, and RA susceptibility has been demonstrated in this study (Saad et al. 2015). The gene discussed is MTHFR; the disease is rheumatoid arthritis.