NFKB1 and neoplasm: Interestingly, a recent study has reported that PAR1 exhibited superior protumor capacity via regulating PI3K/AKT/STAT3/NF-κB signaling whereas PAR4-mediated NF-κB activation notably alleviated tumor growth and metastasis, suggesting the opposite effects of PAR1 and PAR4 in tumor modulation (129).