HPRT1 was upregulated in tumor tissues of bladder urothelial carcinoma (BLCA), BRCA, endocervical adenocarcinoma (CESC), COAD, esophageal carcinoma (ESCA), HNSC, KICH, liver hepatocellular carcinoma (LIHC), LUAD, LUSC, pheochromocytoma, and paraganglioma (PCPG), PRAD, READ, stomach adenocarcinoma (STAD), THCA, and UCEC. Here, HPRT1 is linked to hereditary pheochromocytoma-paraganglioma.