Since the normal groups of adrenocortical carcinomas (ACC), diffuse large B-cell lymphoma (DLBC), acute myeloid leukemia (LAML), lower-grade glioma (LGG), mesothelioma (MESO), ovarian cancer (OV), testicular germ cell tumors (TGCT), uterine carcinosarcoma (UCS), and uveal melanoma (UVM) are missing in the TCGA database, whether there are differences in HPRT1 expression and activity in these tumors needs to be further explored. Here, HPRT1 is linked to central nervous system cancer.