HPRT1 and cancer: The analysis of the differences in tumor microenvironment between high and low HPRT1 expression revealed that in cancers, such as ACC, BRCA, CESC, COAD, HNSC, LAML, LUSC, PAAD, STAD, and UCEC, the ESTIMATEScore was lower in the high HPRT1 expression group compared to the low expression group.