An interesting result was found: in the three heatmaps of immunosuppressants, immunostimulants, and MHC molecules, most of the immune genes in GBM were positively correlated with HPRT1. Most immune genes in PAAD and LUSC were significantly and negatively correlated with HPRTl. In past immunotherapy explorations, the role of HPRT1 in PAAD appears to have been overlooked, requiring further immune-related research. This evidence concerns the gene HPRT1 and glioblastoma.