A total of 16 cuproptosis regulators (FDX1, DLD, LIAS, LIPT1, DLST, DLAT, DBT, GCSH, PDHA1, ATP7A, ATP7B, PDHB, SLC31A1, MTF1, GLS, CDKN2A) were screened according to difference analysis between the control and IDD groups. Here, PDHB is linked to intervertebral disk degenerative disorder.