DNAH8 and intervertebral disk degenerative disorder: Our present study has revealed that these vital cuproptosis modulators in IDD show close correlations with cuproptosis-related mechanisms, which are mainly enriched in biological process (tricarboxylic acid metabolic process), cellular component (mitochondrial matrix), and molecular function (ATPase activity), while their KEGG enrichment analysis showed that Citrate cycle (TCA cycle) was one of the mainly enriched pathways (Figure 2J, 2K).