However, the patients in clusterA with low-risk cuproptosis scores was related to activated CD4 T cell, activated B cell, etc. The adaptive immune response to IDD could be characterized by the activated subsets of T and B cells, and abnormal differentiation of T cells could trigger the overexpression of inflammatory molecules and abnormal expression of B cells, which has a significant connection with IDD [65, 69]. The gene discussed is CD4; the disease is intervertebral disk degenerative disorder.