PSEN2 and Alzheimer disease: Additionally, our study found for the first time that PS2 can bind to Miro2, which is a key player in mitochondrial dynamics in AD, and the PS2 D439A mutation weakens the interaction between PS2 and Miro2 and decreases the expression of Miro2, Mfn1, and Mfn2 and the GTPase activity of Miro2, while the number of Drp1 molecules localized on the OMM increases, which leads to dysfunction of mitochondrial fusion and fission dynamics and changes in mitochondrial morphology.