To identify potential compounds for vitiligo treatment, we performed drug-gene interaction analysis using a combination of DGIdb and The STITCH database on genes related to “melanogenesis”, “tyrosine metabolism”, and “MCODE core module”, including TYR, TRP-1, DCT (TRP-2), MLANA, MC1R, SLC45A2, SOX10, OCA2, KIT, GPR143, MLPH, EDNRB, and ADH7. This evidence concerns the gene GPR143 and vitiligo.