Alzheimer’s disease (AD) neuropathological changes include the intracellular accumulation of hyperphosphorylated tau (p-tau) as neurofibrillary tangles (NFTs) and neuropil threads as well as the aggregation of extracellular amyloid beta (Aβ) plaques [17]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.