However, adolescence is considered a period of particular vulnerability for patients with type 1 diabetes with relatively high rates of depression (Reynolds and Helgeson, 2011), and given the propensity for adherence deterioration and metabolic fluctuations attributed to hormone changing insulin needs, psychosocial distress and simultaneous changes in peer/parental relationships (Helgeson et al., 2018). The gene discussed is INS; the disease is type 1 diabetes mellitus.