In animal models of diabetic db/db mice that have Keap1 gene knockdown (Keap1flox/−) it was shown that NRF2 activation inhibits gluconeogenesis by suppressing several molecular targets (eg, glucose‐6‐phosphatase, fructose‐1,6‐bisphosphatase 1, phosphoenolpyruvate carboxykinase [PCK1], peroxisome proliferator‐activated receptor g coactivator 1‐a, nuclear receptor subfamily 4, group A, member 2), preventing the initiation of diabetes.78 This evidence concerns the gene NFE2L2 and diabetes mellitus.